Keith Harshman, Chief Operations Officer.

  • keith.harshman@health2030.ch

The Health 2030 Genome Center DNA Sequencing Platform has been established to meet the project’s data generation and analysis goals. The goal of the platform is to provide timely, cost-efficient sequencing and data analysis for the large-scale sequencing projects of the Swiss research and clinical communities.

Implementation of the DNA Sequencing Platform (DSP) began in 2017 and was fully operational in 2018 with the establishment of the Health 2030 Genome Center Data Analytics and Interpretation Platform (DAIP), that develops both methods for genome and transcriptome analysis and applies them as a service to users of the Swiss clinical and research community . In addition, the DAIP has put in place a leading-edge data storage and analysis infrastructure.

Starting with purified gDNA or total RNAs provided by the user, the Sequencing Platform services include 1) sample quality assessments, 2) sequencing library preparation and sequencing, and 3) post-run data quality assessments and processing. 

The assay focus of the DNA Sequencing Platform is on whole genome sequencing (WGS), whole exome sequencing (WES) and full transcriptome sequencing (RNA-seq).

Hamilton liquid handling robots, as well as different analytical instruments, are available to support nucleic acid sample quality control and automated sequencing library preparation.

Illumina NovaSeq 6000, HiSeq 4000 and MiSeq sequencers are installed to support services as well as method development activities.

More detailed information is available on the website of the Health 2030 Genome Center.